Drug interactions
Clomipramine + Hyoscyamine spray
Severity: Moderate
Clomipramine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral or sublingual hyoscyamine spray is absorbed systemically and adds antimuscarinic effects to those of clomipramine. This may cause dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Clomipramine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic effects and use the lowest effective hyoscyamine dose. Consider an alternative if urinary retention, ileus or confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Clomipramine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral or sublingual hyoscyamine spray is absorbed systemically and adds antimuscarinic effects to those of clomipramine. This may cause dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Clomipramine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and use the lowest effective hyoscyamine dose. Consider an alternative if urinary retention, ileus or confusion develops.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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