Drug interactions
Clomipramine + Icosapent
Severity: Minor
Clomipramine and Icosapent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may modestly prolong bleeding time, and clomipramine impairs platelet serotonin uptake. Combined use might slightly increase bruising or bleeding, although clinically significant bleeding is uncommon.
What this interaction means in plain words
Clomipramine and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive mild antiplatelet effects from omega-3 fatty acids and serotonin reuptake inhibition.
What to do
No dose change is needed. Monitor for bleeding, especially if anticoagulants or antiplatelet drugs are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Icosapent?
MediHelp rates the interaction as minor. Clomipramine and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent ethyl may modestly prolong bleeding time, and clomipramine impairs platelet serotonin uptake. Combined use might slightly increase bruising or bleeding, although clinically significant bleeding is uncommon.
How serious is the interaction between Clomipramine and Icosapent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for bleeding, especially if anticoagulants or antiplatelet drugs are also used.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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