Drug interactions
Clomipramine + Indacaterol inhaled
Severity: Moderate
Clomipramine and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists, including QT prolongation, tachycardia and arrhythmia. Indacaterol labeling advises extreme caution with these drugs.
What this interaction means in plain words
Clomipramine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and adrenergic cardiovascular stimulation.
What to do
Use indacaterol at the labeled dose and monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Check potassium levels if hypokalemia is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Clomipramine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists, including QT prolongation, tachycardia and arrhythmia. Indacaterol labeling advises extreme caution with these drugs.
How serious is the interaction between Clomipramine and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use indacaterol at the labeled dose and monitor heart rate, palpitations and ECG in patients with cardiac risk factors. Check potassium levels if hypokalemia is a concern.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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