Drug interactions
Clomipramine + Insulin regular human
Severity: Minor
Clomipramine and Insulin regular human: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been associated with altered glycemic control and may enhance the glucose-lowering effect of insulin. Hypoglycemia could be more frequent or less easily recognized in some patients.
What this interaction means in plain words
Clomipramine and Insulin regular human have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; the mechanism is not firmly established.
What to do
Monitor blood glucose more frequently when clomipramine is started, changed or stopped in insulin-treated patients. Adjust the insulin dose if glucose readings change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Insulin regular human?
MediHelp rates the interaction as minor. Clomipramine and Insulin regular human have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been associated with altered glycemic control and may enhance the glucose-lowering effect of insulin. Hypoglycemia could be more frequent or less easily recognized in some patients.
How serious is the interaction between Clomipramine and Insulin regular human?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when clomipramine is started, changed or stopped in insulin-treated patients. Adjust the insulin dose if glucose readings change.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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