Drug interactions
Clomipramine + Iobenguane i
Severity: Major
Clomipramine and Iobenguane i: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine blocks the norepinephrine transporter that takes up iobenguane into target cells. This reduces tumor and tissue uptake and can cause false-negative scans or reduced therapeutic effect.
What this interaction means in plain words
Clomipramine and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of the norepinephrine transporter reduces cellular uptake of iobenguane.
What to do
Stop clomipramine, if clinically feasible, for an adequate washout before iobenguane imaging or therapy, at least 5 half-lives. Coordinate with the prescriber about alternative treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Iobenguane i?
MediHelp rates the interaction as major. Clomipramine and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clomipramine blocks the norepinephrine transporter that takes up iobenguane into target cells. This reduces tumor and tissue uptake and can cause false-negative scans or reduced therapeutic effect.
How serious is the interaction between Clomipramine and Iobenguane i?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop clomipramine, if clinically feasible, for an adequate washout before iobenguane imaging or therapy, at least 5 half-lives. Coordinate with the prescriber about alternative treatment.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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