Drug interactions
Clomipramine + Ketamine
Severity: Moderate
Clomipramine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the central nervous system and combined use may increase sedation and impair psychomotor performance. Ketamine also raises heart rate and blood pressure, and tricyclics may increase the risk of hemodynamic changes and arrhythmias.
What this interaction means in plain words
Clomipramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects and additive sympathomimetic and cardiovascular effects.
What to do
Monitor sedation level, heart rate and blood pressure when ketamine is given to patients on clomipramine. Use the lowest effective ketamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Clomipramine with Ketamine?
MediHelp rates the interaction as moderate. Clomipramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on the central nervous system and combined use may increase sedation and impair psychomotor performance. Ketamine also raises heart rate and blood pressure, and tricyclics may increase the risk of hemodynamic changes and arrhythmias.
How serious is the interaction between Clomipramine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, heart rate and blood pressure when ketamine is given to patients on clomipramine. Use the lowest effective ketamine dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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