Drug interactions
Clomipramine + Ketorolac intranasal
Severity: Moderate
Clomipramine and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine impairs platelet serotonin uptake and ketorolac, even intranasally, inhibits platelet function and can injure the GI mucosa. Together they raise the risk of bleeding, particularly in the upper GI tract.
What this interaction means in plain words
Clomipramine and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation from serotonin reuptake inhibition and cyclooxygenase inhibition, with NSAID mucosal injury.
What to do
Limit ketorolac to the shortest labeled duration and monitor for GI bleeding signs such as melena. Consider gastroprotection in patients at higher risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Clomipramine and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine impairs platelet serotonin uptake and ketorolac, even intranasally, inhibits platelet function and can injure the GI mucosa. Together they raise the risk of bleeding, particularly in the upper GI tract.
How serious is the interaction between Clomipramine and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest labeled duration and monitor for GI bleeding signs such as melena. Consider gastroprotection in patients at higher risk.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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