Drug interactions
Clomipramine + Liotrix
Severity: Moderate
Clomipramine and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix supplies thyroid hormones that increase catecholamine sensitivity, and tricyclics may amplify this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly if thyroid dosing is excessive.
What this interaction means in plain words
Clomipramine and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases adrenergic receptor sensitivity, adding to tricyclic noradrenergic and cardiac effects.
What to do
Monitor heart rate, rhythm and thyroid function tests, and watch for agitation or tremor. Avoid over-replacement with thyroid hormone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Liotrix?
MediHelp rates the interaction as moderate. Clomipramine and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix supplies thyroid hormones that increase catecholamine sensitivity, and tricyclics may amplify this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly if thyroid dosing is excessive.
How serious is the interaction between Clomipramine and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and thyroid function tests, and watch for agitation or tremor. Avoid over-replacement with thyroid hormone.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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