Drug interactions
Clomipramine + Loxapine inhaled
Severity: Moderate
Clomipramine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and clomipramine also has anticholinergic effects that loxapine shares. The combination may increase sedation, and may also add to seizure and QT concerns. Inhaled loxapine can additionally cause bronchospasm.
What this interaction means in plain words
Clomipramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, anticholinergic effects and lowered seizure threshold.
What to do
Monitor sedation, and the ECG in patients with cardiac risk factors. Avoid additional sedatives and observe the patient after loxapine dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Clomipramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and clomipramine also has anticholinergic effects that loxapine shares. The combination may increase sedation, and may also add to seizure and QT concerns. Inhaled loxapine can additionally cause bronchospasm.
How serious is the interaction between Clomipramine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, and the ECG in patients with cardiac risk factors. Avoid additional sedatives and observe the patient after loxapine dosing.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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