Drug interactions
Clomipramine + Lumacaftor / ivacaftor
Severity: Minor
Clomipramine and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces and ivacaftor may inhibit CYP2C19 and other enzymes, so the net effect on clomipramine exposure is unpredictable. Clomipramine levels could fall or rise, affecting efficacy or toxicity.
What this interaction means in plain words
Clomipramine and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mixed CYP induction by lumacaftor and inhibition by ivacaftor, with an uncertain net effect on clomipramine metabolism.
What to do
Monitor clinical response and adverse effects after starting or stopping lumacaftor/ivacaftor. Adjust the clomipramine dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Clomipramine and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces and ivacaftor may inhibit CYP2C19 and other enzymes, so the net effect on clomipramine exposure is unpredictable. Clomipramine levels could fall or rise, affecting efficacy or toxicity.
How serious is the interaction between Clomipramine and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects after starting or stopping lumacaftor/ivacaftor. Adjust the clomipramine dose accordingly.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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