Drug interactions
Clomipramine + Marijuana
Severity: Moderate
Clomipramine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can add to the sedation of clomipramine and may impair cognition and psychomotor skills. Cannabinoids, especially cannabidiol, may inhibit CYP2D6 and CYP2C19, which could raise clomipramine levels. Tachycardia can also occur with tricyclics and cannabis.
What this interaction means in plain words
Clomipramine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible cannabinoid inhibition of CYP2C19/2D6 metabolism of clomipramine.
What to do
Advise against driving and watch for excess sedation, tachycardia and anticholinergic effects. Consider dose reduction if tricyclic toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Marijuana?
MediHelp rates the interaction as moderate. Clomipramine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can add to the sedation of clomipramine and may impair cognition and psychomotor skills. Cannabinoids, especially cannabidiol, may inhibit CYP2D6 and CYP2C19, which could raise clomipramine levels. Tachycardia can also occur with tricyclics and cannabis.
How serious is the interaction between Clomipramine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving and watch for excess sedation, tachycardia and anticholinergic effects. Consider dose reduction if tricyclic toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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