Drug interactions
Clomipramine + Meclizine
Severity: Moderate
Clomipramine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use may cause dry mouth, constipation, urinary retention, blurred vision, confusion and sedation. Older patients and those with glaucoma or prostatic hypertrophy are at greater risk.
What this interaction means in plain words
Clomipramine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and H1 antihistaminic sedation.
What to do
Monitor for anticholinergic toxicity and sedation, and avoid the combination in elderly patients or those with urinary retention or narrow-angle glaucoma. Consider a non-sedating alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Clomipramine with Meclizine?
MediHelp rates the interaction as moderate. Clomipramine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use may cause dry mouth, constipation, urinary retention, blurred vision, confusion and sedation. Older patients and those with glaucoma or prostatic hypertrophy are at greater risk.
How serious is the interaction between Clomipramine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and avoid the combination in elderly patients or those with urinary retention or narrow-angle glaucoma. Consider a non-sedating alternative.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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