Drug interactions
Clomipramine + Meclofenamate
Severity: Moderate
Clomipramine and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs and serotonergic antidepressants such as clomipramine impair platelet aggregation, and NSAIDs damage the gastric mucosa and also inhibit platelets. Together they increase the risk of gastrointestinal bleeding.
What this interaction means in plain words
Clomipramine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clomipramine depletes platelet serotonin while the NSAID inhibits platelet cyclooxygenase and injures gastric mucosa.
What to do
Watch for signs of GI bleeding and use the shortest NSAID course. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Meclofenamate?
MediHelp rates the interaction as moderate. Clomipramine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs and serotonergic antidepressants such as clomipramine impair platelet aggregation, and NSAIDs damage the gastric mucosa and also inhibit platelets. Together they increase the risk of gastrointestinal bleeding.
How serious is the interaction between Clomipramine and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding and use the shortest NSAID course. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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