Drug interactions
Clomipramine + Mestranol
Severity: Minor
Clomipramine and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant concentrations, increasing anticholinergic, sedative and cardiovascular adverse effects. Some reports also suggest a reduced antidepressant response, so the net effect is unpredictable.
What this interaction means in plain words
Clomipramine and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens may inhibit hepatic metabolism of tricyclics; the mechanism is not fully established.
What to do
Monitor for clomipramine adverse effects and for loss of antidepressant response when starting or stopping the estrogen. Adjust the clomipramine dose according to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Mestranol?
MediHelp rates the interaction as minor. Clomipramine and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant concentrations, increasing anticholinergic, sedative and cardiovascular adverse effects. Some reports also suggest a reduced antidepressant response, so the net effect is unpredictable.
How serious is the interaction between Clomipramine and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clomipramine adverse effects and for loss of antidepressant response when starting or stopping the estrogen. Adjust the clomipramine dose according to clinical response.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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