Drug interactions
Clomipramine + Metaproterenol
Severity: Moderate
Clomipramine and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, causing tachycardia, palpitations and arrhythmias. Risk is higher with high doses or underlying heart disease.
What this interaction means in plain words
Clomipramine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clomipramine inhibits norepinephrine reuptake, adding to adrenergic stimulation from metaproterenol.
What to do
Monitor heart rate, rhythm and blood pressure, and use the lowest effective metaproterenol dose. Consider alternative bronchodilators in patients with significant cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Metaproterenol?
MediHelp rates the interaction as moderate. Clomipramine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, causing tachycardia, palpitations and arrhythmias. Risk is higher with high doses or underlying heart disease.
How serious is the interaction between Clomipramine and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and use the lowest effective metaproterenol dose. Consider alternative bronchodilators in patients with significant cardiac disease.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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