Drug interactions
Clomipramine + Methscopolamine
Severity: Moderate
Clomipramine and Methscopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so together they can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are at risk of confusion, ileus and angle-closure glaucoma.
What this interaction means in plain words
Clomipramine and Methscopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive peripheral and central anticholinergic effects.
What to do
Monitor for anticholinergic toxicity, including urinary retention and constipation. Avoid or reduce doses in older patients and those with glaucoma or obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Methscopolamine?
MediHelp rates the interaction as moderate. Clomipramine and Methscopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so together they can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are at risk of confusion, ileus and angle-closure glaucoma.
How serious is the interaction between Clomipramine and Methscopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, including urinary retention and constipation. Avoid or reduce doses in older patients and those with glaucoma or obstruction.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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