Drug interactions
Clomipramine + Metoclopramide intranasal
Severity: Moderate
Clomipramine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects and, rarely, neuroleptic malignant syndrome, and it has serotonergic activity. Clomipramine adds to these risks and is itself a CYP2D6 substrate, while metoclopramide intranasal exposure may be raised by CYP2D6 inhibitors.
What this interaction means in plain words
Clomipramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopaminergic and serotonergic effects, with possible CYP2D6 competition raising metoclopramide levels.
What to do
Monitor for extrapyramidal symptoms, sedation and serotonin toxicity. Consider an alternative antiemetic or prokinetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Clomipramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects and, rarely, neuroleptic malignant syndrome, and it has serotonergic activity. Clomipramine adds to these risks and is itself a CYP2D6 substrate, while metoclopramide intranasal exposure may be raised by CYP2D6 inhibitors.
How serious is the interaction between Clomipramine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and serotonin toxicity. Consider an alternative antiemetic or prokinetic if symptoms develop.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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