Drug interactions
Clomipramine + Midazolam intranasal
Severity: Moderate
Clomipramine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can deepen sedation and impair respiration. Hypoventilation, airway obstruction, desaturation or apnea may occur, especially at higher doses or in vulnerable patients.
What this interaction means in plain words
Clomipramine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and the sedative antihistaminic and anticholinergic effects of clomipramine.
What to do
Use the lowest effective midazolam dose and monitor respiratory rate, oxygen saturation and level of consciousness after dosing. Avoid adding alcohol or other sedatives and ensure the patient is observed until fully recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Clomipramine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can deepen sedation and impair respiration. Hypoventilation, airway obstruction, desaturation or apnea may occur, especially at higher doses or in vulnerable patients.
How serious is the interaction between Clomipramine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor respiratory rate, oxygen saturation and level of consciousness after dosing. Avoid adding alcohol or other sedatives and ensure the patient is observed until fully recovered.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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