Drug interactions
Clomipramine + Octreotide
Severity: Moderate
Clomipramine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of clomipramine. The risk is greater with electrolyte disturbance or underlying heart disease.
What this interaction means in plain words
Clomipramine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac conduction and QT interval, with octreotide-related bradycardia.
What to do
Check a baseline ECG and electrolytes and monitor heart rate and QTc during therapy, especially at initiation or dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Clomipramine with Octreotide?
MediHelp rates the interaction as moderate. Clomipramine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of clomipramine. The risk is greater with electrolyte disturbance or underlying heart disease.
How serious is the interaction between Clomipramine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor heart rate and QTc during therapy, especially at initiation or dose increases.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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