Drug interactions
Clomipramine + Olanzapine / samidorphan
Severity: Moderate
Clomipramine and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and orthostatic hypotension, so combined use raises the risk of dizziness, falls and syncope. Both also have anticholinergic activity and can lower the seizure threshold.
What this interaction means in plain words
Clomipramine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, alpha-1 blockade and anticholinergic effects.
What to do
Monitor blood pressure and sedation, and rise slowly from sitting. Adjust doses in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Clomipramine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and orthostatic hypotension, so combined use raises the risk of dizziness, falls and syncope. Both also have anticholinergic activity and can lower the seizure threshold.
How serious is the interaction between Clomipramine and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, and rise slowly from sitting. Adjust doses in older patients.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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