Drug interactions
Clomipramine + Olanzapine
Severity: Moderate
Clomipramine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects and may prolong the QT interval. Clomipramine can raise olanzapine levels through CYP inhibition, and seizure threshold may be lowered by both agents.
What this interaction means in plain words
Clomipramine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and QT prolongation; possible CYP-mediated metabolic interaction.
What to do
Monitor sedation, anticholinergic effects and ECG in patients with cardiac risk factors. Use the lowest effective doses and watch for seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Clomipramine with Olanzapine?
MediHelp rates the interaction as moderate. Clomipramine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects and may prolong the QT interval. Clomipramine can raise olanzapine levels through CYP inhibition, and seizure threshold may be lowered by both agents.
How serious is the interaction between Clomipramine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, anticholinergic effects and ECG in patients with cardiac risk factors. Use the lowest effective doses and watch for seizures.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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