Drug interactions
Clomipramine + Orphenadrine
Severity: Moderate
Clomipramine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are strongly anticholinergic and sedating, so combined use can cause dry mouth, urinary retention, constipation, confusion and tachycardia. Older patients are particularly vulnerable.
What this interaction means in plain words
Clomipramine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic blockade and CNS depression.
What to do
Monitor for anticholinergic toxicity and sedation. Avoid in older patients and those with glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Orphenadrine?
MediHelp rates the interaction as moderate. Clomipramine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are strongly anticholinergic and sedating, so combined use can cause dry mouth, urinary retention, constipation, confusion and tachycardia. Older patients are particularly vulnerable.
How serious is the interaction between Clomipramine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation. Avoid in older patients and those with glaucoma or urinary retention.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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