Drug interactions
Clomipramine + Panax ginseng
Severity: Minor
Clomipramine and Panax ginseng: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginseng has stimulant-like effects and has been linked to insomnia, agitation and rare reports of mania when combined with antidepressants. It may also affect blood pressure and heart rate, which could add to tricyclic cardiovascular effects.
What this interaction means in plain words
Clomipramine and Panax ginseng have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probable additive central stimulant and cardiovascular effects; the mechanism is not well characterized.
What to do
Ask patients about herbal use and monitor for agitation, insomnia, and changes in blood pressure or heart rate. Stop ginseng if activation or mood elevation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Panax ginseng, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Panax ginseng?
MediHelp rates the interaction as minor. Clomipramine and Panax ginseng have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ginseng has stimulant-like effects and has been linked to insomnia, agitation and rare reports of mania when combined with antidepressants. It may also affect blood pressure and heart rate, which could add to tricyclic cardiovascular effects.
How serious is the interaction between Clomipramine and Panax ginseng?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and monitor for agitation, insomnia, and changes in blood pressure or heart rate. Stop ginseng if activation or mood elevation occurs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
