Drug interactions
Clomipramine + Phendimetrazine
Severity: Major
Clomipramine and Phendimetrazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic, and with a tricyclic it can cause excess adrenergic stimulation, including hypertension, tachycardia and arrhythmias. Tricyclics may also alter responses to indirectly acting amines.
What this interaction means in plain words
Clomipramine and Phendimetrazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive noradrenergic effects: clomipramine blocks norepinephrine reuptake and phendimetrazine promotes catecholamine release.
What to do
Avoid the combination if possible. If used, monitor blood pressure, heart rate and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Phendimetrazine?
MediHelp rates the interaction as major. Clomipramine and Phendimetrazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phendimetrazine is a sympathomimetic anorectic, and with a tricyclic it can cause excess adrenergic stimulation, including hypertension, tachycardia and arrhythmias. Tricyclics may also alter responses to indirectly acting amines.
How serious is the interaction between Clomipramine and Phendimetrazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor blood pressure, heart rate and ECG.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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