Drug interactions
Clomipramine + Phenylephrine po
Severity: Moderate
Clomipramine and Phenylephrine po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can enhance the pressor effect of direct-acting sympathomimetics such as phenylephrine. This may lead to hypertension and arrhythmias, although oral phenylephrine has low bioavailability.
What this interaction means in plain words
Clomipramine and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clomipramine blocks norepinephrine reuptake and sensitizes adrenergic receptors, enhancing the effect of phenylephrine.
What to do
Monitor blood pressure and heart rate, and avoid high or repeated doses. Suggest non-pressor symptomatic alternatives for cold symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Phenylephrine po?
MediHelp rates the interaction as moderate. Clomipramine and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can enhance the pressor effect of direct-acting sympathomimetics such as phenylephrine. This may lead to hypertension and arrhythmias, although oral phenylephrine has low bioavailability.
How serious is the interaction between Clomipramine and Phenylephrine po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid high or repeated doses. Suggest non-pressor symptomatic alternatives for cold symptoms.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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