Drug interactions
Clomipramine + Pipemidic acid
Severity: Moderate
Clomipramine and Pipemidic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pipemidic acid is a potent CYP1A2 inhibitor and may raise clomipramine concentrations, which are partly cleared by CYP1A2. Higher levels could increase anticholinergic, sedative, cardiac and seizure risks.
What this interaction means in plain words
Clomipramine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated clomipramine metabolism by pipemidic acid.
What to do
Monitor for tricyclic toxicity such as dry mouth, sedation, tremor and palpitations, and consider reducing the clomipramine dose. Quinolones may also lower seizure threshold, so watch for seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Pipemidic acid?
MediHelp rates the interaction as moderate. Clomipramine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pipemidic acid is a potent CYP1A2 inhibitor and may raise clomipramine concentrations, which are partly cleared by CYP1A2. Higher levels could increase anticholinergic, sedative, cardiac and seizure risks.
How serious is the interaction between Clomipramine and Pipemidic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity such as dry mouth, sedation, tremor and palpitations, and consider reducing the clomipramine dose. Quinolones may also lower seizure threshold, so watch for seizures.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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