Drug interactions
Clomipramine + Pirbuterol
Severity: Moderate
Clomipramine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine may potentiate the cardiac and vascular effects of pirbuterol, raising the risk of tachycardia and arrhythmia. The effect is unpredictable between patients.
What this interaction means in plain words
Clomipramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block noradrenaline reuptake and may enhance adrenergic responses to beta-agonists.
What to do
Monitor pulse, blood pressure and ECG if symptoms arise, and keep the pirbuterol dose as low as effective. Switch bronchodilator if significant cardiac effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Pirbuterol?
MediHelp rates the interaction as moderate. Clomipramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine may potentiate the cardiac and vascular effects of pirbuterol, raising the risk of tachycardia and arrhythmia. The effect is unpredictable between patients.
How serious is the interaction between Clomipramine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse, blood pressure and ECG if symptoms arise, and keep the pirbuterol dose as low as effective. Switch bronchodilator if significant cardiac effects occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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