Drug interactions
Clomipramine + Progesterone micronized
Severity: Minor
Clomipramine and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sex hormones have been reported to alter tricyclic antidepressant exposure and response. Concentrations of the tricyclic may rise with more adverse effects, or antidepressant effect may be reduced, and the evidence is limited.
What this interaction means in plain words
Clomipramine and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible altered hepatic metabolism of the tricyclic; the mechanism is not clearly established.
What to do
Monitor for sedation, anticholinergic effects and changes in depressive symptoms when hormone therapy is started or stopped. Adjust the clomipramine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Progesterone micronized?
MediHelp rates the interaction as minor. Clomipramine and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sex hormones have been reported to alter tricyclic antidepressant exposure and response. Concentrations of the tricyclic may rise with more adverse effects, or antidepressant effect may be reduced, and the evidence is limited.
How serious is the interaction between Clomipramine and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and changes in depressive symptoms when hormone therapy is started or stopped. Adjust the clomipramine dose if needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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