Drug interactions
Clomipramine + Quazepam
Severity: Moderate
Clomipramine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and combining it with clomipramine increases sedation, psychomotor impairment and fall risk. Effects are greater in older adults and with alcohol.
What this interaction means in plain words
Clomipramine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression via GABA-A potentiation and the sedative properties of clomipramine.
What to do
Use the lowest effective quazepam dose for the shortest time and monitor for excessive sedation and falls. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Quazepam?
MediHelp rates the interaction as moderate. Clomipramine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic, and combining it with clomipramine increases sedation, psychomotor impairment and fall risk. Effects are greater in older adults and with alcohol.
How serious is the interaction between Clomipramine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quazepam dose for the shortest time and monitor for excessive sedation and falls. Advise avoiding alcohol and driving.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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