Drug interactions
Clomipramine + Quinacrine
Severity: Moderate
Clomipramine and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and thereby raise concentrations of clomipramine and its active metabolite, potentially increasing tricyclic toxicity. Cardiac conduction effects and anticholinergic symptoms may become more prominent.
What this interaction means in plain words
Clomipramine and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metabolism of clomipramine.
What to do
Monitor for signs of tricyclic toxicity and consider an ECG and plasma level monitoring. Reduce the clomipramine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Quinacrine?
MediHelp rates the interaction as moderate. Clomipramine and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6 and thereby raise concentrations of clomipramine and its active metabolite, potentially increasing tricyclic toxicity. Cardiac conduction effects and anticholinergic symptoms may become more prominent.
How serious is the interaction between Clomipramine and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tricyclic toxicity and consider an ECG and plasma level monitoring. Reduce the clomipramine dose if adverse effects appear.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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