Drug interactions
Clomipramine + Remimazolam
Severity: Moderate
Clomipramine and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedative benzodiazepine with a sedating tricyclic antidepressant can produce deeper than expected sedation and respiratory depression. Profound sedation, hypoxia or hypotension may occur during procedures.
What this interaction means in plain words
Clomipramine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and sedative antihistaminic and anticholinergic effects of clomipramine.
What to do
Titrate remimazolam carefully to effect and continuously monitor oxygen saturation, respiration and blood pressure through recovery. Have airway support and reversal available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Clomipramine with Remimazolam?
MediHelp rates the interaction as moderate. Clomipramine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedative benzodiazepine with a sedating tricyclic antidepressant can produce deeper than expected sedation and respiratory depression. Profound sedation, hypoxia or hypotension may occur during procedures.
How serious is the interaction between Clomipramine and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully to effect and continuously monitor oxygen saturation, respiration and blood pressure through recovery. Have airway support and reversal available.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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