Drug interactions
Clomipramine + Salicylates
Severity: Moderate
Clomipramine and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine inhibits platelet serotonin uptake, which can impair platelet aggregation and add to the bleeding tendency and gastric mucosal injury caused by salicylates. The risk is highest with higher salicylate doses, advanced age and prior ulcer disease.
What this interaction means in plain words
Clomipramine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of hemostasis from reduced platelet serotonin and salicylate effects on platelets and gastric mucosa.
What to do
Monitor for signs of gastrointestinal bleeding and bruising, and consider gastroprotection in high-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Salicylates, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Salicylates?
MediHelp rates the interaction as moderate. Clomipramine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine inhibits platelet serotonin uptake, which can impair platelet aggregation and add to the bleeding tendency and gastric mucosal injury caused by salicylates. The risk is highest with higher salicylate doses, advanced age and prior ulcer disease.
How serious is the interaction between Clomipramine and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and bruising, and consider gastroprotection in high-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
