Drug interactions
Clomipramine + Salsalate
Severity: Moderate
Clomipramine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate prodrug with NSAID-like activity, and clomipramine's serotonin reuptake inhibition may add to the risk of gastrointestinal bleeding. Salsalate has weaker platelet effects than aspirin, so the increase in risk is probably modest.
What this interaction means in plain words
Clomipramine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function and gastric mucosal injury from serotonin reuptake inhibition and salicylate action.
What to do
Monitor for signs of gastrointestinal bleeding and consider gastroprotection in patients with ulcer history or older age.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Salsalate?
MediHelp rates the interaction as moderate. Clomipramine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate prodrug with NSAID-like activity, and clomipramine's serotonin reuptake inhibition may add to the risk of gastrointestinal bleeding. Salsalate has weaker platelet effects than aspirin, so the increase in risk is probably modest.
How serious is the interaction between Clomipramine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider gastroprotection in patients with ulcer history or older age.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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