Drug interactions
Clomipramine + Same
Severity: Moderate
Clomipramine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) may have serotonergic activity and, with clomipramine, which strongly inhibits serotonin reuptake, could contribute to serotonin syndrome. Reported cases are limited but agitation, tremor, sweating and hyperthermia are possible.
What this interaction means in plain words
Clomipramine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; the mechanism for SAMe is not firmly established.
What to do
Avoid routine combined use and counsel the patient to report agitation, tremor, sweating or diarrhea. Stop SAMe if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Same?
MediHelp rates the interaction as moderate. Clomipramine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) may have serotonergic activity and, with clomipramine, which strongly inhibits serotonin reuptake, could contribute to serotonin syndrome. Reported cases are limited but agitation, tremor, sweating and hyperthermia are possible.
How serious is the interaction between Clomipramine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combined use and counsel the patient to report agitation, tremor, sweating or diarrhea. Stop SAMe if serotonin toxicity is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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