Drug interactions
Clomipramine + Scullcap
Severity: Minor
Clomipramine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap has traditional sedative properties and may add to the drowsiness caused by clomipramine. Product quality varies and clinical data are scarce.
What this interaction means in plain words
Clomipramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probable additive CNS depression, possibly via GABAergic activity of skullcap constituents.
What to do
Advise patients to avoid skullcap or monitor for excessive sedation, and caution against driving until the effect is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Scullcap?
MediHelp rates the interaction as minor. Clomipramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap has traditional sedative properties and may add to the drowsiness caused by clomipramine. Product quality varies and clinical data are scarce.
How serious is the interaction between Clomipramine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid skullcap or monitor for excessive sedation, and caution against driving until the effect is known.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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