Drug interactions
Clomipramine + Selegiline transdermal
Severity: Contraindicated
Clomipramine and Selegiline transdermal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline transdermal is a monoamine oxidase inhibitor, and combining it with clomipramine, a potent serotonin reuptake inhibitor, can cause serotonin syndrome and hypertensive reactions. The label contraindicates use with tricyclic antidepressants. Reactions can be severe and life-threatening.
What this interaction means in plain words
Clomipramine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition together with serotonin and norepinephrine reuptake blockade produces excess synaptic monoamines.
What to do
Do not co-administer. Allow a washout of at least 2 weeks after stopping selegiline before starting clomipramine, and at least 2 weeks after stopping clomipramine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Clomipramine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline transdermal is a monoamine oxidase inhibitor, and combining it with clomipramine, a potent serotonin reuptake inhibitor, can cause serotonin syndrome and hypertensive reactions. The label contraindicates use with tricyclic antidepressants. Reactions can be severe and life-threatening.
How serious is the interaction between Clomipramine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow a washout of at least 2 weeks after stopping selegiline before starting clomipramine, and at least 2 weeks after stopping clomipramine before starting selegiline.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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