Drug interactions
Clomipramine + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Clomipramine and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine lowers the seizure threshold, and bowel preparations can cause fluid and electrolyte disturbances such as hyponatremia and hypokalemia, which also provoke seizures. Electrolyte shifts may additionally increase the risk of arrhythmia with a tricyclic antidepressant.
What this interaction means in plain words
Clomipramine and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive seizure risk from a lowered seizure threshold plus bowel-prep-induced electrolyte and fluid disturbances.
What to do
Ensure adequate hydration and correct baseline electrolyte abnormalities before the bowel preparation. Counsel patients to report seizure, confusion or palpitations; consider checking electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Clomipramine and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine lowers the seizure threshold, and bowel preparations can cause fluid and electrolyte disturbances such as hyponatremia and hypokalemia, which also provoke seizures. Electrolyte shifts may additionally increase the risk of arrhythmia with a tricyclic antidepressant.
How serious is the interaction between Clomipramine and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and correct baseline electrolyte abnormalities before the bowel preparation. Counsel patients to report seizure, confusion or palpitations; consider checking electrolytes in high-risk patients.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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