Drug interactions
Clomipramine + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Clomipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine can cause SIADH-type hyponatremia, and osmotic bowel preparations can produce fluid shifts and electrolyte loss. Together they may increase the risk of hyponatremia, water retention, and associated seizures or confusion.
What this interaction means in plain words
Clomipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on water and sodium balance (antidepressant-related SIADH plus bowel-prep fluid and electrolyte shifts).
What to do
Maintain adequate hydration with electrolyte-containing fluids and avoid excessive plain water intake during the preparation. Check sodium beforehand and afterwards in older patients or those with prior hyponatremia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Clomipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine can cause SIADH-type hyponatremia, and osmotic bowel preparations can produce fluid shifts and electrolyte loss. Together they may increase the risk of hyponatremia, water retention, and associated seizures or confusion.
How serious is the interaction between Clomipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain adequate hydration with electrolyte-containing fluids and avoid excessive plain water intake during the preparation. Check sodium beforehand and afterwards in older patients or those with prior hyponatremia.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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