Drug interactions
Clomipramine + Sufentanil sl
Severity: Major
Clomipramine and Sufentanil sl: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a potent serotonin reuptake inhibitor, and opioids with serotonergic activity may contribute to serotonin syndrome. Additive CNS and respiratory depression also occurs, and clomipramine may increase opioid effects.
What this interaction means in plain words
Clomipramine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity plus additive CNS and respiratory depression.
What to do
Monitor for agitation, tremor, hyperreflexia, hyperthermia and sedation, especially at initiation and dose changes. Use the lowest effective sufentanil dose and stop either agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Sufentanil sl?
MediHelp rates the interaction as major. Clomipramine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clomipramine is a potent serotonin reuptake inhibitor, and opioids with serotonergic activity may contribute to serotonin syndrome. Additive CNS and respiratory depression also occurs, and clomipramine may increase opioid effects.
How serious is the interaction between Clomipramine and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, hyperthermia and sedation, especially at initiation and dose changes. Use the lowest effective sufentanil dose and stop either agent if serotonin syndrome is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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