Drug interactions
Clomipramine + Sulfasalazine
Severity: Minor
Clomipramine and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine impairs platelet serotonin uptake and can modestly raise bleeding tendency, particularly in the upper gastrointestinal tract. Sulfasalazine may itself cause gastrointestinal irritation or blood dyscrasias, so the combination may increase bleeding concern.
What this interaction means in plain words
Clomipramine and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Serotonin reuptake inhibition by clomipramine impairs platelet function, adding to mucosal injury risk.
What to do
Monitor for signs of gastrointestinal bleeding such as black stools or anemia. Consider gastroprotection in patients with additional risk factors such as NSAID use or prior ulcers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Sulfasalazine?
MediHelp rates the interaction as minor. Clomipramine and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clomipramine impairs platelet serotonin uptake and can modestly raise bleeding tendency, particularly in the upper gastrointestinal tract. Sulfasalazine may itself cause gastrointestinal irritation or blood dyscrasias, so the combination may increase bleeding concern.
How serious is the interaction between Clomipramine and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding such as black stools or anemia. Consider gastroprotection in patients with additional risk factors such as NSAID use or prior ulcers.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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