Drug interactions
Clomipramine + Sumatriptan intranasal
Severity: Moderate
Clomipramine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with serotonergic antidepressants have been associated with serotonin syndrome. The reported risk is low, but symptoms such as agitation, tremor, hyperthermia and autonomic instability can be serious.
What this interaction means in plain words
Clomipramine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic stimulation from 5-HT1B/1D agonism and serotonin reuptake inhibition.
What to do
Counsel the patient on serotonin syndrome symptoms and use the lowest effective sumatriptan dose. Stop both drugs and seek care if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Clomipramine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with serotonergic antidepressants have been associated with serotonin syndrome. The reported risk is low, but symptoms such as agitation, tremor, hyperthermia and autonomic instability can be serious.
How serious is the interaction between Clomipramine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on serotonin syndrome symptoms and use the lowest effective sumatriptan dose. Stop both drugs and seek care if symptoms develop.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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