Drug interactions
Clomipramine + Thiothixene
Severity: Moderate
Clomipramine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have anticholinergic and hypotensive properties, so together they increase drowsiness and other adverse effects. Clomipramine may raise antipsychotic levels via CYP2D6 inhibition, and both lower the seizure threshold.
What this interaction means in plain words
Clomipramine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, anticholinergic effects and seizure-threshold lowering, with possible pharmacokinetic interaction.
What to do
Monitor sedation, blood pressure, anticholinergic effects and ECG, and use the lowest effective doses. Counsel patients regarding driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Thiothixene?
MediHelp rates the interaction as moderate. Clomipramine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have anticholinergic and hypotensive properties, so together they increase drowsiness and other adverse effects. Clomipramine may raise antipsychotic levels via CYP2D6 inhibition, and both lower the seizure threshold.
How serious is the interaction between Clomipramine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure, anticholinergic effects and ECG, and use the lowest effective doses. Counsel patients regarding driving and fall risk.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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