Drug interactions
Clomipramine + Thyroid desiccated
Severity: Moderate
Clomipramine and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can increase sensitivity to catecholamines and tricyclic antidepressants may enhance this effect. The combination can increase the risk of tachycardia and arrhythmia, and may also increase CNS stimulation, although thyroid hormone is sometimes used deliberately to augment antidepressants.
What this interaction means in plain words
Clomipramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased adrenergic receptor sensitivity from thyroid hormone adds to the noradrenergic effects of clomipramine.
What to do
Monitor heart rate, rhythm and symptoms of thyrotoxicosis or agitation, and keep the thyroid dose at the lowest effective level. Use ECG monitoring in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Thyroid desiccated?
MediHelp rates the interaction as moderate. Clomipramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can increase sensitivity to catecholamines and tricyclic antidepressants may enhance this effect. The combination can increase the risk of tachycardia and arrhythmia, and may also increase CNS stimulation, although thyroid hormone is sometimes used deliberately to augment antidepressants.
How serious is the interaction between Clomipramine and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and symptoms of thyrotoxicosis or agitation, and keep the thyroid dose at the lowest effective level. Use ECG monitoring in patients with cardiac disease.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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