Drug interactions
Clomipramine + Tobacco use
Severity: Minor
Clomipramine and Tobacco use: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking induces hepatic enzymes and can lower clomipramine concentrations, possibly reducing clinical effect. Stopping smoking can allow levels to rise with more adverse effects.
What this interaction means in plain words
Clomipramine and Tobacco use have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP1A2 by tobacco smoke hydrocarbons increases clomipramine metabolism.
What to do
Assess response and adjust the clomipramine dose if needed in smokers. Monitor for toxicity and consider dose reduction if the patient stops smoking.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Tobacco use?
MediHelp rates the interaction as minor. Clomipramine and Tobacco use have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Smoking induces hepatic enzymes and can lower clomipramine concentrations, possibly reducing clinical effect. Stopping smoking can allow levels to rise with more adverse effects.
How serious is the interaction between Clomipramine and Tobacco use?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess response and adjust the clomipramine dose if needed in smokers. Monitor for toxicity and consider dose reduction if the patient stops smoking.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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