Drug interactions
Clomipramine + Topiramate
Severity: Moderate
Clomipramine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, cognitive slowing and dizziness, so sedation and impaired concentration may be greater together. Both can also lower seizure threshold or cause other CNS effects, and topiramate may add to anticholinergic-type effects such as heat intolerance.
What this interaction means in plain words
Clomipramine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through different pharmacodynamic mechanisms.
What to do
Titrate both drugs gradually and monitor for excess sedation and cognitive impairment. Advise caution with driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Clomipramine with Topiramate?
MediHelp rates the interaction as moderate. Clomipramine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, cognitive slowing and dizziness, so sedation and impaired concentration may be greater together. Both can also lower seizure threshold or cause other CNS effects, and topiramate may add to anticholinergic-type effects such as heat intolerance.
How serious is the interaction between Clomipramine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both drugs gradually and monitor for excess sedation and cognitive impairment. Advise caution with driving and alcohol.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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