Drug interactions
Clomipramine + Trifluoperazine
Severity: Major
Clomipramine and Trifluoperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and together they raise the risk of ventricular arrhythmia. They also add sedation and anticholinergic effects, and clomipramine may raise phenothiazine levels via CYP2D6 competition.
What this interaction means in plain words
Clomipramine and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and CNS and anticholinergic effects, with possible CYP2D6 competition.
What to do
Avoid if alternatives exist. If used together, obtain an ECG, correct electrolytes and monitor for sedation and anticholinergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Trifluoperazine?
MediHelp rates the interaction as major. Clomipramine and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, and together they raise the risk of ventricular arrhythmia. They also add sedation and anticholinergic effects, and clomipramine may raise phenothiazine levels via CYP2D6 competition.
How serious is the interaction between Clomipramine and Trifluoperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist. If used together, obtain an ECG, correct electrolytes and monitor for sedation and anticholinergic toxicity.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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