Drug interactions
Clomipramine + Tropisetron
Severity: Moderate
Clomipramine and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may raise the risk of arrhythmia including torsades de pointes. The effect is greater with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Clomipramine and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation.
What to do
Obtain an ECG if the patient has risk factors and correct potassium and magnesium. Consider a different antiemetic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Tropisetron?
MediHelp rates the interaction as moderate. Clomipramine and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may raise the risk of arrhythmia including torsades de pointes. The effect is greater with electrolyte disturbance or cardiac disease.
How serious is the interaction between Clomipramine and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG if the patient has risk factors and correct potassium and magnesium. Consider a different antiemetic if the QTc is prolonged.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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