Drug interactions
Clomipramine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Clomipramine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of the long-acting beta agonist vilanterol, including tachycardia, hypertension and QT prolongation. Umeclidinium adds anticholinergic effects.
What this interaction means in plain words
Clomipramine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic and QT effects, with additive anticholinergic effects from umeclidinium.
What to do
Use only if the benefit outweighs the risk and monitor heart rate, blood pressure and ECG as appropriate. Watch for palpitations, and for urinary retention and dry mouth from anticholinergic load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Umeclidinium bromide / vilanterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Clomipramine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of the long-acting beta agonist vilanterol, including tachycardia, hypertension and QT prolongation. Umeclidinium adds anticholinergic effects.
How serious is the interaction between Clomipramine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if the benefit outweighs the risk and monitor heart rate, blood pressure and ECG as appropriate. Watch for palpitations, and for urinary retention and dry mouth from anticholinergic load.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
