Drug interactions
Clomipramine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Clomipramine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may potentiate the cardiovascular effects of vilanterol, including tachycardia, hypertension and QT prolongation. The effect is greatest in patients with existing heart disease.
What this interaction means in plain words
Clomipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation and QT prolongation.
What to do
Monitor heart rate, blood pressure and ECG in patients at risk. Use the lowest effective doses and consider alternatives in patients with arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Clomipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may potentiate the cardiovascular effects of vilanterol, including tachycardia, hypertension and QT prolongation. The effect is greatest in patients with existing heart disease.
How serious is the interaction between Clomipramine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients at risk. Use the lowest effective doses and consider alternatives in patients with arrhythmia.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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