Drug interactions
Clonazepam + Gabapentin enacarbil
Severity: Moderate
Clonazepam and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with a gabapentinoid increases sedation and the risk of respiratory depression, particularly in older patients or those with lung disease.
What this interaction means in plain words
Clonazepam and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Take extra care in the elderly and in patients with COPD or concurrent opioid use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Clonazepam with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Clonazepam and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with a gabapentinoid increases sedation and the risk of respiratory depression, particularly in older patients or those with lung disease.
How serious is the interaction between Clonazepam and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Take extra care in the elderly and in patients with COPD or concurrent opioid use.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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